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37 RCTs Meta-Analysis (2020) Weight loss: -1.13 kg BMI: -0.36 points Fat mass: -1.16 kg Waist circumference: -1.24 cm Umbrella Meta-Analysis (2025) Confirms: statistically significant weight loss , especially combined with exercise
These may include mental health conditions like depression or anxiety, or physical limitations that prevent you from exercising without pain
Thyroid 21 (9), 957963
NICE guidance says medicines for overweight and obesity should be used with diet and physical activity support, rather than as standalone treatment
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